In monotherapy considerations, there are occasions when Avandia may be more optimal than the primarily recommended Glipizide, and instances when a drug combination plan utilizing both may be warranted. Thus, both the patient and drug characteristics must be evaluated relative to each other to determine the proper course of therapy. Diabetes mellitus is a complex group of syndromes applied to disturbances in the oxidation and utilization of glucose. This occurs secondary to a malfunction of the beta cells of the pancreas, which are responsible for the production of insulin. Insulin is involved in the metabolism of carbohydrates, fats, and proteins. Diabetes mellitus can be classified as type 1 (juvenile) or type 2 (adult onset), the latter of which is discussed here. In type 2 diabetes a metabolic abnormality exists, characterizing this syndrome with insulin deficiency, insulin resistance, and increased hepatic glucose output.