Medicinal substance’s quality is a vital facet throughout the life due to its importance as acceptance at receiver’s end. Guidelines have been laid out for the evaluation, mitigation and review systems of drug regulatory systems. For manufacturing medicinal products, quality management system has become a crucial part in the process. The principles of quality risk management in the procedures of deviation control, change control, investigations of market complaints and batch failures are dealt with the risks of quality management during manufacture. There are cases yet to be resolved which are related to customer complaints and batch failures whose roots reside in the poor distribution of pharmaceutical products. There will be no useful preventive plan which would be related to risk factors in the absence of an established quality risk management system during product shipment. A superfluous system of quality risk management during manufacturing has been imposed during the distribution of pharmaceutical products with the help of this study. The quality risk management drawn in the pharmaceutical distribution would be useful to avoid market queries and problems, drug withdrawals and regulatory actions. This study gives us information about an uncommon model solution for industry officials and policymakers for widening up scope to prevent the recalling and rejection of the product and thereby paving the way for substantial business.