Coronary Heart Disease: Molecular and Cellular Aspects

A focus on the molecular and celllular events during the development of an atheroma in coronary heart disease.

This paper examines how coronary heart disease is a killer and how it is predominantly affected by the chronic inflammatory reaction occurring in the subendothelium of the artery. It builds a picture of the cascade of events that occur to form a fatal atheroma in the coronary arteries, illustrated with experimental evidence obtained from experiments with transgenic mice.
“The blood supply to the heart is referred to as the coronary blood supply. This is provided by the left and right coronary arteries, which are subdivisions pf the coronary artery that joins the aorta just above the mitral valve. The right coronary artery supplies the right atrial and ventricular myocardium, whereas the left coronary artery splits into the left circumflex artery supplying the left atrial and ventricular myocardium, and the left anterior descending artery which supplies the left ventricular and right ventricular myocardium. Most notably there are no anatomises in the coronary circulation. Therefore, occlusion of any of the arteries will result in severely reduced perfusion to the area usually supplied by that artery. This leads to ischemia, and eventual cell death, fibrosis and loss of function. Therefore the coronary blood supply is particularly venerable to arterial disease that causes arterial occlusion.”